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Metabolism. 2016 Aug;65(8):1080-6. doi: 10.1016/j.metabol.2015.11.008. Epub 2015 Dec 2.

Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Author information

1
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.
2
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: kleinerd@mail.nih.gov.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the liver injury most often associated with disorders of insulin resistance, including obesity, diabetes and the metabolic syndrome. The term encompasses several patterns of liver injury, including a relatively benign condition of steatosis without hepatocellular injury, nonalcoholic steatohepatitis (NASH), and a pattern of zone 1 steatosis, inflammation and fibrosis mainly observed in prepubertal children. Staging and grading systems have been developed to characterize the histological changes in NAFLD, mainly as a tool for clinical research. The histological features of NAFLD across these different manifestations and the scoring systems used to evaluate disease severity are discussed.

KEYWORDS:

Histology; Liver biopsy; Steatohepatitis; Steatosis

PMID:
26775559
PMCID:
PMC4889547
DOI:
10.1016/j.metabol.2015.11.008
[Indexed for MEDLINE]
Free PMC Article

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