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Cytokine Growth Factor Rev. 2016 Apr;28:21-9. doi: 10.1016/j.cytogfr.2015.12.004. Epub 2016 Jan 2.

Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway.

Author information

1
Novel Drug Delivery Lab, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
2
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Nanotechnology Research center, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran. Electronic address: chopin1827@yahoo.com.
3
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Nanotechnology Research center, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran.
4
Nephrology and Urology research center, Baqiyatallah medical science university, Tehran, Iran.

Abstract

NF-κB pathway has long been considered as one of the potent prototypical pro-inflammatory signaling pathway and its role in several aspects of human health has been established. Recent studies have suggested that NF-κB activation is the master key in early development and pathobiology of several Cancers. Curcumin is a polyphenolic phytochemical compound with several stablished anti-inflammatory properties and is known to exert its anti-inflammatory effects mostly by interrupting NF-κB signaling pathway at multiple stages. Here we tried to provide a summary of recent finding, focusing on introducing NF-κB signaling pathways and its potential mechanism involved in development of several types of Cancers.

KEYWORDS:

Cancer; Curcumin; Inflammation; NF-κB

PMID:
26774676
DOI:
10.1016/j.cytogfr.2015.12.004
[Indexed for MEDLINE]

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