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J Affect Disord. 2016 Mar 15;193:175-84. doi: 10.1016/j.jad.2015.12.071. Epub 2015 Dec 31.

Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder.

Author information

1
Division of Child & Adolescent Psychiatry, UCLA Semel Institute for Neurosciences, 760 Westwood Plaza, Los Angeles, CA 90024-1759, United States.
2
Division of Adult Psychiatry, UCLA Semel Institute for Neurosciences, Los Angeles, CA, United States.
3
Division of Child & Adolescent Psychiatry, UCLA Semel Institute for Neurosciences, 760 Westwood Plaza, Los Angeles, CA 90024-1759, United States. Electronic address: joneill@mednet.ucla.edu.

Abstract

BACKGROUND:

fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD.

METHODS:

Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD.

RESULTS:

As in adults, the global metric small-worldness was significantly (P<0.05) lower in patients than controls, by 13.5% (%mean difference=100%X(OCD mean - control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P<0.01), suggesting less granular - or differently organized - functional brain parcellation. Higher clustering coefficients (23.9-32.4%, P<0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (-63.6%, P<0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain regions at these sites.

LIMITATIONS:

Relatively large node size; relatively small sample size, comorbidities in some patients.

CONCLUSIONS:

Pediatric OCD patients demonstrate aberrant global and local resting-state network connectivity topologies compared to healthy children. Local results accord with recent views of OCD as a disorder with sensorimotor component.

KEYWORDS:

Frontal pole; Obsessive-compulsive disorder; Sensorimotor cortex; Supplementary motor cortex; fMRI graph theory

PMID:
26773910
PMCID:
PMC5767329
DOI:
10.1016/j.jad.2015.12.071
[Indexed for MEDLINE]
Free PMC Article

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