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Neurosci Lett. 2016 Feb 12;614:77-82. doi: 10.1016/j.neulet.2016.01.002. Epub 2016 Jan 7.

Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice.

Author information

1
College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan Province, PR China.
2
College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan Province, PR China. Electronic address: liyucheng@hactcm.edu.cn.

Abstract

Depression is increasingly become a global public healthy problem. This study was to investigate whether berberine could attenuate the depressive-like behavior induced by repeated corticosterone injection and explore the possible mechanisms. The present results showed that exogenous corticosterone injection caused depressive-like behaviors in mice, such as decreased sucrose intake in sucrose preference test (SPT) and increased immobility time in forced swimming test (FST). These behavioral alterations were accompanying with the decreased BDNF mRNA and protein levels in hippocampus and the elevated serum corticosterone levels. Treatment with berberine prevented these changes above. Our findings confirmed the antidepressant-like effect of berberine and suggested its mechanisms might be partially mediated by up-regulation of BDNF in hippocampus.

KEYWORDS:

Berberine; Brain-derived neurotrophic factor; Corticosterone; Depression

PMID:
26773864
DOI:
10.1016/j.neulet.2016.01.002
[Indexed for MEDLINE]

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