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Curr Opin Struct Biol. 2016 Apr;37:71-80. doi: 10.1016/j.sbi.2015.12.004. Epub 2016 Jan 8.

Protein sequence design and its applications.

Author information

1
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
2
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India; IISc Mathematics Initiative, Indian Institute of Science, Bangalore 560 012, India.
3
National Centre for Biological Sciences-TIFR, UAS-GKVK Campus, Bangalore 560065, India.
4
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India. Electronic address: ns@mbu.iisc.ernet.in.

Abstract

Design of proteins has far-reaching potentials in diverse areas that span repurposing of the protein scaffold for reactions and substrates that they were not naturally meant for, to catching a glimpse of the ephemeral proteins that nature might have sampled during evolution. These non-natural proteins, either in synthesized or virtual form have opened the scope for the design of entities that not only rival their natural counterparts but also offer a chance to visualize the protein space continuum that might help to relate proteins and understand their associations. Here, we review the recent advances in protein engineering and design, in multiple areas, with a view to drawing attention to their future potential.

PMID:
26773478
DOI:
10.1016/j.sbi.2015.12.004
[Indexed for MEDLINE]

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