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Curr Opin Struct Biol. 2016 Apr;37:62-70. doi: 10.1016/j.sbi.2015.12.003. Epub 2016 Jan 7.

How dynein and dynactin transport cargos: a structural perspective.

Author information

1
MRC Lab of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom. Electronic address: cartera@mrc-lmb.cam.ac.uk.
2
MRC Lab of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.

Abstract

Recent structures of the dynein motor in three different conformations reveal how it uses ATP hydrolysis to move along microtubules. Attention is now turning to how cytoplasmic dynein-1 and dynactin act together to carry cargos. Cryo-electron microscopy (cryo-EM) has revealed the structure of dynactin and how it binds dynein in the presence of a cargo adaptor protein Bicaudal-D2 (BICD2). Future questions will include how dynein-1 transports so many different cargos and how the 2.4MDa dynein/dynactin transport machine is regulated.

PMID:
26773477
DOI:
10.1016/j.sbi.2015.12.003
[Indexed for MEDLINE]
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