Format

Send to

Choose Destination
Bioinformatics. 2016 May 15;32(10):1493-501. doi: 10.1093/bioinformatics/btw018. Epub 2016 Jan 14.

FINEMAP: efficient variable selection using summary data from genome-wide association studies.

Author information

1
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Public Health, University of Helsinki, Helsinki, Finland.
2
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
3
National Institute for Health and Welfare (THL), Helsinki, Finland and.
4
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Public Health, University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
5
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

Abstract

MOTIVATION:

The goal of fine-mapping in genomic regions associated with complex diseases and traits is to identify causal variants that point to molecular mechanisms behind the associations. Recent fine-mapping methods using summary data from genome-wide association studies rely on exhaustive search through all possible causal configurations, which is computationally expensive.

RESULTS:

We introduce FINEMAP, a software package to efficiently explore a set of the most important causal configurations of the region via a shotgun stochastic search algorithm. We show that FINEMAP produces accurate results in a fraction of processing time of existing approaches and is therefore a promising tool for analyzing growing amounts of data produced in genome-wide association studies and emerging sequencing projects.

AVAILABILITY AND IMPLEMENTATION:

FINEMAP v1.0 is freely available for Mac OS X and Linux at http://www.christianbenner.com

CONTACT:

: christian.benner@helsinki.fi or matti.pirinen@helsinki.fi.

PMID:
26773131
PMCID:
PMC4866522
DOI:
10.1093/bioinformatics/btw018
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center