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Adv Nutr. 2016 Jan 15;7(1):44-65. doi: 10.3945/an.115.009639. Print 2016 Jan.

Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links.

Author information

1
Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Bedford Park, IL; and Department of Nutrition, University of California, Davis, CA bburton@iit.edu.
2
Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Bedford Park, IL; and.

Abstract

Diet is an essential factor that affects the risk of modern-day metabolic diseases, including cardiovascular disease, diabetes mellitus, obesity, and Alzheimer disease. The potential ability of certain foods and their bioactive compounds to reverse or prevent the progression of the pathogenic processes that underlie these diseases has attracted research attention. Red raspberries (Rubus idaeus L.) are unique berries with a rich history and nutrient and bioactive composition. They possess several essential micronutrients, dietary fibers, and polyphenolic components, especially ellagitannins and anthocyanins, the latter of which give them their distinctive red coloring. In vitro and in vivo studies have revealed various mechanisms through which anthocyanins and ellagitannins (via ellagic acid or their urolithin metabolites) and red raspberry extracts (or the entire fruit) could reduce the risk of or reverse metabolically associated pathophysiologies. To our knowledge, few studies in humans are available for evaluation. We review and summarize the available literature that assesses the health-promoting potential of red raspberries and select components in modulating metabolic disease risk, especially cardiovascular disease, diabetes mellitus, obesity, and Alzheimer disease-all of which share critical metabolic, oxidative, and inflammatory links. The body of research is growing and supports a potential role for red raspberries in reducing the risk of metabolically based chronic diseases.

KEYWORDS:

anthocyanins; cardiovascular disease; diabetes; ellagic acid; inflammation; oxidative stress; polyphenols; red raspberries

PMID:
26773014
PMCID:
PMC4717884
DOI:
10.3945/an.115.009639
[Indexed for MEDLINE]
Free PMC Article

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