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J Neuroinflammation. 2016 Jan 16;13:10. doi: 10.1186/s12974-016-0476-z.

Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer's disease.

Author information

1
Department of Physiology, College of Korean Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemoon-ku, Seoul, 130-701, Republic of Korea. jh486ms22@naver.com.
2
Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), 70, Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea. hschung@kiom.re.kr.
3
Department of Physiology, College of Korean Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemoon-ku, Seoul, 130-701, Republic of Korea. lcj8078@naver.com.
4
Department of Physiology, College of Korean Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemoon-ku, Seoul, 130-701, Republic of Korea. anstlr72@hanmail.net.
5
Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, University of Science and Technology, #215-4 Gongneug-dong, Nowon-ku, Seoul, 139-241, Republic of Korea. yar11@hanmail.net.
6
Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, University of Science and Technology, #215-4 Gongneug-dong, Nowon-ku, Seoul, 139-241, Republic of Korea. kjs@kirams.re.kr.
7
Department of Obstetrics and Gynecology, College of Korean Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemoon-ku, Seoul, 130-701, Republic of Korea. soulhus@khu.ac.kr.
8
Acupuncture and Meridian Science Research Center, College of Korean Medical Science Graduate School, Kyung Hee University, #1 Hoegi-dong, Dongdaemoon-ku, Seoul, 130-701, Republic of Korea. ishim@khu.ac.kr.
9
Department of Physiology, College of Korean Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemoon-ku, Seoul, 130-701, Republic of Korea. hbae@khu.ac.kr.

Abstract

BACKGROUND:

Alzheimer's disease (AD) is a severe neuroinflammatory disease. CD4(+)Foxp3(+) regulatory T cells (Tregs) modulate various inflammatory diseases via suppressing Th cell activation. There are increasing evidences that Tregs have beneficial roles in neurodegenerative diseases. Previously, we found the population of Treg cells was significantly increased by bee venom phospholipase A2 (bvPLA2) treatment in vivo and in vitro.

METHODS:

To examine the effects of bvPLA2 on AD, bvPLA2 was administered to 3xTg-AD mice, mouse model of Alzheimer's disease. The levels of amyloid beta (Aβ) deposits in the hippocampus, glucose metabolism in the brain, microglia activation, and CD4(+) T cell infiltration were analyzed to evaluate the neuroprotective effect of bvPLA2.

RESULTS:

bvPLA2 treatment significantly enhanced the cognitive function of the 3xTg-AD mice and increased glucose metabolism, as assessed with 18F-2 fluoro-2-deoxy-D-glucose ([F-18] FDG) positron emission tomography (PET). The levels of Aβ deposits in the hippocampus were dramatically decreased by bvPLA2 treatment. This neuroprotective effect of bvPLA2 was associated with microglial deactivation and reduction in CD4(+) T cell infiltration. Interestingly, the neuroprotective effects of bvPLA2 were abolished in Treg-depleted mice.

CONCLUSIONS:

The present studies strongly suggest that the increase of Treg population by bvPLA2 treatment might inhibit progression of AD in the 3xTg AD mice.

PMID:
26772975
PMCID:
PMC4715334
DOI:
10.1186/s12974-016-0476-z
[Indexed for MEDLINE]
Free PMC Article

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