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Cell Metab. 2016 Jan 12;23(1):10-2. doi: 10.1016/j.cmet.2015.12.012.

Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes.

Author information

1
Science for Life Laboratory, KTH - Royal Institute of Technology, 171 21 Stockholm, Sweden; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden. Electronic address: adilm@scilifelab.se.
2
Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
3
Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Lundberg Laboratory for Diabetes Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Abstract

Type 2 diabetes (T2D) is associated with dysbiosis of the gut microbiota, though diabetes treatment regimens, including metformin, may confound the results. Forslund et al. (2015) identify distinct disease and drug signatures and highlight the importance of adjusting for treatment when investigating how T2D influences the human gut microbiome.

PMID:
26771114
DOI:
10.1016/j.cmet.2015.12.012
[Indexed for MEDLINE]
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