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Biomed Res Int. 2015;2015:183469. doi: 10.1155/2015/183469. Epub 2015 Dec 6.

Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury.

Author information

1
Department of Surgery, University of Florida, Gainesville, FL 32610, USA.

Abstract

Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondrial dysfunction is a cardinal event culminating in hepatic reperfusion injury. Mitochondrial autophagy, so-called mitophagy, is a key cellular process that regulates mitochondrial homeostasis and eliminates damaged mitochondria in a timely manner. Growing evidence accumulates that I/R injury is attributed to defective mitophagy. This review aims to summarize the current understanding of autophagy and its role in hepatic I/R injury and highlight the various therapeutic approaches that have been studied to ameliorate injury.

PMID:
26770970
PMCID:
PMC4684839
DOI:
10.1155/2015/183469
[Indexed for MEDLINE]
Free PMC Article

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