Format

Send to

Choose Destination
Prev Nutr Food Sci. 2015 Dec;20(4):298-302. doi: 10.3746/pnf.2015.20.4.298. Epub 2015 Dec 31.

Anti-Obesity Effects of Starter Fermented Kimchi on 3T3-L1 Adipocytes.

Author information

1
Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National University, Busan 46241, Korea.
2
Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National University, Busan 46241, Korea; Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, People's Republic of China.

Abstract

The anti-obesity effects of starter (Leuconostoc mesenteroides+Lactobacillus plantarum) fermented kimchi on 3T3-L1 adipocyte were studied using naturally fermented kimchi (NK), a functional kimchi (FK, NK supplemented with green tea), and FK supplemented with added starters (FKS). Oil red O staining and cellular levels of triglyceride (TG) and glycerol were used to evaluate the in vitro anti-obesity effects of these kimchis in 3T3-L1 cells. The expressions of adipogenesis/lipogenesis-related genes of peroxisome proliferator-active receptor (PPAR)-γ, CCAAT/enhance-binding protein (C/EBP)-α, and fatty acid synthase (FAS) were determined by RT-PCR. Kimchis, especially FKS, markedly decreased TG levels and increased levels of intracellular glycerol and lipid lipolysis. In addition, FKS also reduced the mRNA levels of PPAR-γ, C/EBP-α, and FAS, which are related to adipogenesis/lipogenesis in 3T3-L1 cells. These results suggest the anti-obesity effects of FKS were to due to enhanced lipolysis and reduced adipogenesis/lipogenesis in 3T3-L1 adipocytes.

KEYWORDS:

3T3-L1 cells; antiobesity; kimchi; starters

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center