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Biochim Biophys Acta. 2016 May;1862(5):878-86. doi: 10.1016/j.bbadis.2015.12.023. Epub 2016 Jan 5.

Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons.

Author information

1
Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina Street, IL 60612, Chicago, USA. Electronic address: Alifiya_Kapasi@rush.edu.
2
Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina Street, IL 60612, Chicago, USA. Electronic address: Julie_A_Schneider@rush.edu.

Abstract

There is growing evidence suggesting that vascular pathologies and dysfunction play a critical role in cognitive impairment, clinical Alzheimer's disease, and dementia. Vascular pathologies such as macroinfarcts, microinfarcts, microbleeds, small and large vessel cerebrovascular disease, and white matter disease are common especially in the brains of older persons where they contribute to cognitive impairment and lower the dementia threshold. Vascular dysfunction resulting in decreased cerebral blood flow, and abnormalities in the blood brain barrier may also contribute to the Alzheimer's disease (AD) pathophysiologic process and AD dementia. This review provides a clinical-pathological perspective on the role of vessel disease, vascular brain injury, alterations of the neurovascular unit, and mixed pathologies in the Alzheimer's disease pathophysiologic process and Alzheimer's dementia. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

KEYWORDS:

Alzheimer's disease; Dementia; Mixed pathologies; Neuropathology; Vascular

PMID:
26769363
DOI:
10.1016/j.bbadis.2015.12.023
[Indexed for MEDLINE]
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