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Items: 2

1.
Hautarzt. 1989 Aug;40(8):490-5.

[Low dosage retinol and L-cystine combination improve alopecia of the diffuse type following long-term oral administration].

[Article in German]

Author information

  • 1Universit├Ąts-Hautklinik und Poliklinik, Freien Universit├Ąt Berlin.

Abstract

In a pilot study (I) the efficacy of a new combination therapy for hair loss of the diffuse type was tested in 36 patients, followed by a double blind study with 47 patients. The daily dosage was 18,000 IE retinol, 70 mg L-cystine and 7000 mg gelatin. The clinical efficacy was evaluated by standard methods, such as the preparation of trichograms and measurement of the hair density before and after treatment. The pilot study demonstrated a significant improvement, with reduction of the telogen rate by 8.3%, an increase of the anagen rate by 11%, and an increase of the hair density by 6.9%. In the double blind study (II) the trichogram showed a significant decrease of the telogen rate by 13.5% compared with pathological baseline values. There was no change in the placebo group. The lowered anagen rate of 47.2% was improved by 8%, whereas the mean value in the placebo group decreased from 47.7% to 39.9%. In addition, the percentage of dysplastic anagen hairs improved by 7.4%, as against further impairment with an increase of 26% in the placebo group. During oral therapy no systemic side-effects were detected. We conclude that long-term oral therapy with high doses of L-cystine and gelatin in combination with vitamin A may have beneficial effects on diffuse hair loss.

PMID:
2676911
[PubMed - indexed for MEDLINE]
2.
Boll Soc Ital Biol Sper. 1983 Jan 31;59(1):20-5.

[Gelatin-cystine, keratogenesis and structure of the hair].

[Article in Italian]

Abstract

It is known how noticeable modifications may be induced in the high sulphur content proteins of wool, by enrichment of the diet of sheep with cysteine or sulphur amino acids. It is also well known how the oral ingestion of gelatin significantly increases hair diameter and the degree of hardness of finger and toe nails. To the end of verifying the possible stimulating selective action performed by cystine and gelatin in the keratinization processes of the hairy structures, it was controlled: amino acids content in hair of normal rat after oral ingestion of a controlled quantity of gelatin-cystine added in the diet. The same experiments have been carried out on rats in which the condition of sufference of the hair was induced by means of a biotin-free diet. From the obtained data it seems that gelatin-cystine, added in the diet of normal or suffering rats, helps to modify the cysteine content of the sulphur-rich hair proteins (+ 50% abt.). The diet supplement bring about a considerable increasing of CYS (+ 35%) with a decreasing of GLY (- 15%).

PMID:
6189501
[PubMed - indexed for MEDLINE]

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