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Annu Rev Med. 2016;67:261-72. doi: 10.1146/annurev-med-051214-025146.

Vitamin D and Cardiovascular Disease.

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Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232; email:


Vitamin D is best known for its influence on skeletal health. There is growing recognition, however, that vitamin D has nonskeletal actions, which could have important implications for understanding the consequences of vitamin D deficiency. In epidemiologic studies, vitamin D deficiency has been consistently associated with an increased risk for cardiovascular disease and hypertension. Disruption of vitamin D signaling in animal models promotes hypertension, cardiac hypertrophy, and atherosclerosis. This evidence has led to the initiation of prospective randomized trials of vitamin D supplementation in individuals at risk for cardiovascular disease. The results of these trials should help to guide strategies for screening and management of vitamin D deficiency in the clinic and at the population level.


cardiovascular disease; prevention; vitamin D

[Indexed for MEDLINE]

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