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Chron Respir Dis. 2016 May;13(2):162-72. doi: 10.1177/1479972315626014. Epub 2016 Jan 14.

Respiratory and lower limb muscle function in interstitial lung disease.

Author information

1
Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK mariopanag@gmail.com.
2
Hygeia General Hospital, Athens, Greece.
3
Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC, USA.

Abstract

Growing evidence suggests that respiratory and limb muscle function may be impaired in patients with interstitial lung disease (ILD). Importantly, muscle dysfunction could promote dyspnoea, fatigue and functional limitation all of which are cardinal features of ILD. This article examines the risk factors for skeletal muscle dysfunction in ILD, reviews the current evidence on overall respiratory and limb muscle function and focuses on the occurrence and implications of skeletal muscle dysfunction in ILD. Research limitations and pathways to address the current knowledge gaps are highlighted.

KEYWORDS:

Interstitial lung disease; muscle dysfunction; respiratory muscles; risk factors; skeletal muscle

PMID:
26768011
PMCID:
PMC5734592
DOI:
10.1177/1479972315626014
[Indexed for MEDLINE]
Free PMC Article

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