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Am J Obstet Gynecol. 2016 Mar;214(3):321-7. doi: 10.1016/j.ajog.2015.12.061. Epub 2016 Jan 6.

Human amniotic fluid: a source of stem cells for possible therapeutic use.

Author information

1
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, NY.
2
Department of Pathology, New York University Langone Medical Center, New York, NY.
3
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, NY. Electronic address: Bruce.young@nyumc.org.

Abstract

Stem cells are undifferentiated cells with the capacity for differentiation. Amniotic fluid cells have emerged only recently as a possible source of stem cells for clinical purposes. There are no ethical or sampling constraints for the use of amniocentesis as a standard clinical procedure for obtaining an abundant supply of amniotic fluid cells. Amniotic fluid cells of human origin proliferate rapidly and are multipotent with the potential for expansion in vitro to multiple cell lines. Tissue engineering technologies that use amniotic fluid cells are being explored. Amniotic fluid cells may be of clinical benefit for fetal therapies, degenerative disease, and regenerative medicine applications. We present a comprehensive review of the evolution of human amniotic fluid cells as a possible modality for therapeutic use.

KEYWORDS:

amniotic fluid; stem cell; therapy; transplantation

Comment in

PMID:
26767797
DOI:
10.1016/j.ajog.2015.12.061
[Indexed for MEDLINE]

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