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Am J Physiol Regul Integr Comp Physiol. 2016 Mar 15;310(6):R481-92. doi: 10.1152/ajpregu.00349.2015. Epub 2016 Jan 13.

Delayed growth, motor function and learning in preterm pigs during early postnatal life.

Author information

1
Comparative Pediatrics and Nutrition, Department of Veterinary Clinical and Animal Science, Frederiksberg C, Denmark;
2
Comparative Pediatrics and Nutrition, Department of Veterinary Clinical and Animal Science, Frederiksberg C, Denmark; Departments of Neonatology and Pediatrics, Copenhagen University Hospital (Rigshospitalet), Copenhagen Ø, Denmark; and.
3
Nutricia Research, Utrecht, Netherlands;
4
Department of Veterinary Sciences, University of Antwerp, Wilrijk, Belgium.
5
Departments of Neonatology and Pediatrics, Copenhagen University Hospital (Rigshospitalet), Copenhagen Ø, Denmark; and.
6
Comparative Pediatrics and Nutrition, Department of Veterinary Clinical and Animal Science, Frederiksberg C, Denmark; thomas.thymann@sund.ku.dk.

Abstract

Preterm birth interrupts normal fetal growth with consequences for postnatal growth and organ development. In preterm infants, many physiological deficits adapt and disappear with advancing postnatal age, but some may persist into childhood. We hypothesized that preterm birth would induce impaired organ growth and function during the first postnatal week in pigs, while motor abilities and behavioral characteristics would show more persistent developmental delay. Cesarean-delivered preterm (n = 112, 90% gestation) or term (n = 56, 100% gestation) piglets were reared under identical conditions and euthanized for blood and organ collection on postnatal days 0, 5, or 26. Body weight gain remained lower in preterm vs. term pigs up to day 26 (25.5 ± 1.5 vs. 31.0 ± 0.5 g·kg(-1)·day(-1), P < 0.01) when relative weights were higher for brain and kidneys and reduced for liver and spleen. Neonatal preterm pigs had reduced values for blood pH, Po2, glucose, lactate, hematocrit, and cortisol, but at day 26, most values were normalized, although plasma serotonin and IGF 1 levels remained reduced. Preterm pigs showed delayed neonatal arousal and impaired physical activity, coordination, exploration, and learning, relative to term pigs (all P < 0.05). Supplementation of parenteral nutrition during the first 5 days with an enteral milk diet did not affect later outcomes. In preterm pigs, many physiological characteristics of immaturity disappeared by 4 wk, while some neurodevelopmental deficits remained. The preterm pig is a relevant animal model to study early dietary and pharmacological interventions that support postnatal maturation and neurodevelopment in preterm infants.

KEYWORDS:

behavior; neurodevelopment; preterm birth

PMID:
26764054
DOI:
10.1152/ajpregu.00349.2015
[Indexed for MEDLINE]
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