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Trends Neurosci. 2016 Jan;39(1):16-25. doi: 10.1016/j.tins.2015.11.004.

Oscillations and Episodic Memory: Addressing the Synchronization/Desynchronization Conundrum.

Author information

1
University of Birmingham, School of Psychology, Birmingham, UK. Electronic address: s.hanslmayr@bham.ac.uk.
2
University of Birmingham, School of Psychology, Birmingham, UK.
3
University of Birmingham, School of Psychology, Birmingham, UK; University of Kent, School of Computing, Canterbury, UK.

Abstract

Brain oscillations are one of the core mechanisms underlying episodic memory. However, while some studies highlight the role of synchronized oscillatory activity, others highlight the role of desynchronized activity. We here describe a framework to resolve this conundrum and integrate these two opposing oscillatory behaviors. Specifically, we argue that the synchronization and desynchronization reflect a division of labor between a hippocampal and a neocortical system, respectively. We describe a novel oscillatory framework that integrates synchronization and desynchronization mechanisms to explain how the two systems interact in the service of episodic memory.

KEYWORDS:

MTL; alpha/beta; complementary learning systems; cross-frequency coupling; episodic memory; gamma; hippocampus; oscillations; theta

PMID:
26763659
PMCID:
PMC4819444
DOI:
10.1016/j.tins.2015.11.004
[Indexed for MEDLINE]
Free PMC Article

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