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Drug Dev Res. 2016 Feb;77(1):29-36. doi: 10.1002/ddr.21289. Epub 2016 Jan 13.

Antihyperalgesic Activity of Rhodiola rosea in a Diabetic Rat Model.

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Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional (IPN), México, D.F., 11340, México.
Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", México, D.F., México.
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México, D.F., México.
Laboratorio de Farmacología de la Unidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamulipas.


Preclinical Research Rhodiola rosea L. (Crassulaceae) is used for enhancing physical and mental performance. Recent studies demonstrated that R. rosea had anti-inflammatory activity in animal models, for example, carrageenan- and nystatin-induced edema in rats, possibly by inhibiting phospholipase A2 and cyclooxygenases-1 and -2. In addition, R. rosea had antinociceptive activity in thermal and chemical pain tests as well as mechanical hyperalgesia. The purpose of the present study was to assess the antihyperalgesic effect of an ethanol extract of Rhodiola rosea (R. rosea) in a diabetic rat model. Rats were administered a single dose of streptozotocin (STZ; 50 mg/kg, i.p.) and hyperalgesia was evaluated four weeks later. Formalin-evoked (0.5%) flinching was increased in diabetic rats compared with nondiabetic controls Systemic (1-100 mg/kg, i.p.) and local (0.1-10 mg/paw into the dorsal surface of the right hind paw) administration of R. rosea ethanol extract dose-dependently reduced formalin-induced hyperalgesia in diabetic rats. The antihyperalgesic effect of R. rosea was compared with gabapentin. These results suggest that R. rosea ethanol extract may have potential as a treatment for diabetic hyperalgesia.


Rhodiola rosea; diabetic painful neuropathy; hyperalgesia; nociception

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