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Clin Genet. 1989 Sep;36(3):178-82.

The contribution of HLA to rheumatoid arthritis.

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Department of Rheumatology, Royal Victoria Infirmary, Newcastle University, Newcastle-upon-Tyne, England.


The contribution of genes within the major histocompatibility complex to rheumatoid arthritis has been calculated (Rotter & Landaw 1984). Separate data from hospital- and population-based studies of monozygotic twin concordance rates and sibling recurrence risks have been used, along with material from published haplotype-sharing studies. Using either source of information gives the same result, a contribution of 37%.

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