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Korean J Food Sci Anim Resour. 2015;35(5):707-13. doi: 10.5851/kosfa.2015.35.5.707. Epub 2015 Oct 31.

Whitening Effect of Watersoluble Royal Jelly from South Korea.

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Department of Agricultural Biology, National Academy of Agricultural Science, Wanju 55365, Korea.
Catholic University of Daegu School of Medicine, Daegu 42472, Korea.
School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW 2795, Australia.


Royal jelly has been widely used as a health supplement worldwide. However, royal jelly has been implicated in allergic reactions, and we developed a water-soluble royal jelly (WSRJ) without the allergy inducing protein. In this study, we aimed to identify the anti-melanogenic efficacy of WSRJ. B16F1 melanoma cells were first treated with 10 nM α-melanocyte stimulating hormone (α-MSH) and then with various doses of WSRJ. In addition, we investigated the mRNA and protein expression of melanogenesis-related genes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2 by reverse transcription-polymerase chain reaction and western blotting. WSRJ directly inhibited tyrosinase and cellular tyrosinase activity, which decreased melanin synthesis in α-MSH stimulated B16F1 melanoma cells a level comparable to that observed with arbutin. WSRJ decreased the mRNA and protein expressions of tyrosinase, TRP-1, and TRP-2, which was comparable to that observed with arbutin. WSRJ has strong anti-melanogenic activity, which invoice direct inhibition of tyrosinase enzyme activity and suppression of expression of melanogenesis related genes. Results from this study suggests that WSRJ is a potential candidate for the treatment of skin pigmentation.


TRP-1; TRP-2; royal jelly; tyrosinase; water-soluble royal jelly; α-MSH

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