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Drug Chem Toxicol. 2016 Oct;39(4):392-9. doi: 10.3109/01480545.2015.1130718. Epub 2016 Jan 12.

Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage.

Author information

1
a Laboratorio De Toxicología Experimental , Facultad De Ciencias Bioquímicas Y Farmacéuticas, Universidad Nacional De Rosario , Rosario , Argentina and.
2
b Laboratorio De Reproducción Y Lactancia , IMBECU, CONICET, CCT CONICET Mendoza , Mendoza , Argentina.

Abstract

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is used on a wide variety of terrestrial and aquatic broadleaf weeds. 2,4-D has been shown to produce a wide range of adverse effects on animal and human health. The aim of the current study was to evaluate the effects of pre- and postnatal exposure to 2,4-D on rat ventral prostate (VP). Pregnant rats were exposed daily to oral doses of 70 mg/kg/day of 2,4-D from 16 days of gestation up to 23 days after delivery. Then, the treated groups (n = 8) were fed with a 2,4-D added diet until sacrificed by decapitation on postnatal day (PND) 45, 60, or 90. Morphometric studies were performed and androgen receptor (AR) protein levels in the VP were determined. AR, insulin-like growth factor-I (IGF-1) and insulin-like growth factor-I receptor (IGF-1R) mRNA expression in the VP along with testosterone (T), dihydroxytestosterone (DHT), growth hormone (GH) and IGF-1 serum levels were also determined to ascertain whether these parameters were differentially affected. Results of this study showed that 2,4-D exposure during gestation and until adulthood altered development of the prostate gland in male rats, delaying it at early ages while increasing its size in adults, indicate that 2,4-D could behave as endocrine disruptors (EDs).

KEYWORDS:

2,4-Dichlorophenoxyacetic herbicide; androgen receptor; developmental toxicity; hormone

PMID:
26759115
DOI:
10.3109/01480545.2015.1130718
[Indexed for MEDLINE]

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