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Blood. 2016 Feb 18;127(7):801-9. doi: 10.1182/blood-2015-09-618538. Epub 2016 Jan 12.

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology.

Author information

1
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Cell Biology.
2
Department of Pediatrics, and.
3
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Cell Biology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.

Abstract

Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic anemia, episodic vaso-occlusion, and progressive organ damage. Current management of the disease remains symptomatic or preventative. Specific treatment targeting major complications such as vaso-occlusion is still lacking. Recent studies have identified various cellular and molecular factors that contribute to the pathophysiology of SCD. Here, we review the role of these elements and discuss the opportunities for therapeutic intervention.

PMID:
26758915
PMCID:
PMC4760086
DOI:
10.1182/blood-2015-09-618538
[Indexed for MEDLINE]
Free PMC Article

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