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Sci Rep. 2016 Jan 13;6:19171. doi: 10.1038/srep19171.

Support for the Microgenderome: Associations in a Human Clinical Population.

Author information

1
Psychology Department, Victoria University, Victoria, Australia.
2
Bioscreen (Aust) Pty Ltd, Victoria, Australia.
3
CFS Discovery Clinic, Donvale, Victoria, Australia.

Abstract

The 'microgenderome' provides a paradigm shift that highlights the role of sex differences in the host-microbiota interaction relevant for autoimmune and neuro-immune conditions. Analysis of cross-sectional self-report and faecal microbial data from 274 patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) suggests that commensal gut microorganisms may play both protective and deleterious roles in symptom expression. Results revealed significant sex-specific interactions between Firmicutes (Clostridium, Streptococcus, Lactobacillus and Enterococcus) and ME/CFS symptoms (including neurological, immune and mood symptoms), regardless of compositional similarity in microbial levels across the sexes. Extending animal studies, we provide support for the microgenderome in a human clinical population. Applied and mechanistic research needs to consider sex-interactions when examining the composition and function of human microbiota.

PMID:
26757840
PMCID:
PMC4725945
DOI:
10.1038/srep19171
[Indexed for MEDLINE]
Free PMC Article

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