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J Magn Reson Imaging. 2016 Jun;43(6):1500-6. doi: 10.1002/jmri.25127. Epub 2016 Jan 12.

Alterations of neocortico-limbic association fibers and correlation with diet in prediabetes diagnosed by impaired fasting glucose.

Hou YC1, Yang SH2, Wu YT3,4,5, Lai CH3,4,6.

Author information

1
Department of Nutrition, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, ROC.
2
School of Nutrition and Health Sciences, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan, ROC.
3
Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan, ROC.
4
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
5
Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC.
6
Department of Psychiatry, Cheng Hsin General Hospital, Taipei City, Taiwan, ROC.

Abstract

PURPOSE:

To assess the existence of alterations in the micro-integrity of the fasciculus in prediabetic subjects. The issue of micro-integrity in white matter tracts has not been adequately addressed in prediabetes.

MATERIALS AND METHODS:

Sixty-four prediabetic subjects and 54 controls were enrolled. All participants completed 24-hour diet records and 3-day diet records and received diffusion tensor imaging at 3T. The data for white matter micro-integrity were analyzed and compared between prediabetic subjects and controls with age and gender as covariates. In addition, voxel-wise regression between white matter micro-integrity, diet, and preprandial glucose levels were used to explore the relationship between white matter micro-integrity and diet or serum glucose levels.

RESULTS:

We found that prediabetic subjects had significant reductions in the micro-integrity of bilateral anterior thalamic radiation, left inferior longitudinal fasciculus, and left superior longitudinal fasciculus (corrected P < 0.05). In addition, total carbohydrate intake amount and preprandial serum glucose levels were negatively correlated with the micro-integrity in the left inferior longitudinal fasciculus and left anterior thalamic radiation (r: -0.47, corrected P < 0.05).

CONCLUSION:

Restrictive alterations in the white matter micro-integrity of the anterior thalamic radiation and inferior and superior longitudinal fasciculi might represent the initial "hot spots" for white matter tract alterations, which might play a role in the development of prediabetes. J. Magn. Reson. Imaging 2016;43:1500-1506.

KEYWORDS:

anterior thalamic radiation; inferior longitudinal fasciculus; prediabetes; superior longitudinal fasciculus; white matter

PMID:
26756544
DOI:
10.1002/jmri.25127
[Indexed for MEDLINE]

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