Format

Send to

Choose Destination
FEMS Microbiol Lett. 2016 Feb;363(4). pii: fnw004. doi: 10.1093/femsle/fnw004. Epub 2016 Jan 10.

Metabolic modeling of clostridia: current developments and applications.

Author information

1
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802-1503, USA.
2
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802-1503, USA costas@engr.psu.edu.

Abstract

Anaerobic Clostridium spp. is an important bioproduction microbial genus that can produce solvents and utilize a broad spectrum of substrates including cellulose and syngas. Genome-scale metabolic (GSM) models are increasingly being put forth for various clostridial strains to explore their respective metabolic capabilities and suitability for various bioconversions. In this study, we have selected representative GSM models for six different clostridia (Clostridium acetobutylicum, C. beijerinckii, C. butyricum, C. cellulolyticum, C. ljungdahlii and C. thermocellum) and performed a detailed model comparison contrasting their metabolic repertoire. We also discuss various applications of these GSM models to guide metabolic engineering interventions as well as assessing cellular physiology.

KEYWORDS:

Wood-Ljungdahl pathway; cellulotytic; clostridia; genome scale metabolic modeling; solventogenic

PMID:
26755502
DOI:
10.1093/femsle/fnw004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center