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Am J Transplant. 2016 Jan;16 Suppl 2:99-114. doi: 10.1111/ajt.13669.

Intestine.

Author information

1
Department of Pediatrics, University of Washington, Seattle, WA.
2
Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN.
3
Liver and Intestine Transplantation Program, Seattle Children's Hospital, Seattle, WA.
4
Organ Procurement and Transplantation Network, Richmond, VA.
5
United Network for Organ Sharing, Richmond, VA.
6
Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
7
Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN.

Abstract

Intestine and intestine-liver transplant plays an important role in the treatment of intestinal failure, despite decreased morbidity associated with parenteral nutrition. In 2014, 210 new patients were added to the intestine transplant waiting list. Among prevalent patients on the list at the end of 2014, 65% were waiting for an intestine transplant and 35% were waiting for an intestine-liver transplant. The pretransplant mortality rate decreased dramatically over time for all age groups. Pretransplant mortality was highest for adult candidates, at 22.1 per 100 waitlist years compared with less than 3 per 100 waitlist years for pediatric candidates, and notably higher for candidates for intestine-liver transplant than for candidates for intestine transplant without a liver. Numbers of intestine transplants without a liver increased from a low of 51 in 2013 to 67 in 2014. Intestine-liver transplants increased from a low of 44 in 2012 to 72 in 2014. Short-gut syndrome (congenital and other) was the main cause of disease leading to both intestine and intestine-liver transplant. Graft survival improved over the past decade. Patient survival was lowest for adult intestine-liver recipients and highest for pediatric intestine recipients.

KEYWORDS:

Intestinal failure; intestine transplant; intestine-liver transplant; waiting list

PMID:
26755265
DOI:
10.1111/ajt.13669
[Indexed for MEDLINE]
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