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J Cell Biol. 2016 Jan 18;212(2):139-41. doi: 10.1083/jcb.201512092. Epub 2016 Jan 11.

Muscle versus Snail: Muscle wins.

Author information

1
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada.
2
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada u.tepass@utoronto.ca.

Abstract

Epithelial-mesenchymal transitions (EMTs) are often governed by the transcription factor Snail and entail the loss of apical junctions from epithelial cells. In this issue, Weng and Wieschaus (2016. J Cell Biol. http://dx.doi.org/10.1083/jcb.201508056) report that actomyosin contractility can strengthen junctions to override Snail-dependent junctional disassembly and postpone EMT during Drosophila melanogaster gastrulation.

PMID:
26754649
PMCID:
PMC4738388
DOI:
10.1083/jcb.201512092
[Indexed for MEDLINE]
Free PMC Article

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