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J Diabetes. 2017 Jan;9(1):45-52. doi: 10.1111/1753-0407.12375. Epub 2016 Mar 9.

Clinical characteristics of Chinese patients with duration of type 2 diabetes >40 years.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
2
Department of Endocrinology, Peking University People's Hospital, Beijing, China.
3
Department of Acupuncture, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Abstract

BACKGROUND:

Although type 2 diabetes mellitus (T2DM) shortens life expectancy by 10-12 years, some patients survive extremely long durations of diabetes. The clinical characteristics of Chinese patients with >40 years T2DM remain unknown. Thus, the aim of the present study was to document the clinical profile of patients with T2DM for ≥40 years.

METHODS:

The present study evaluated 157 survivors with >40 years T2DM from a total of 582 773 patients with T2DM enrolled in a Chinese national survey of HbA1c. Two matched case-control studies were performed on long T2DM survivors (cases) separately matched according to: (1) survey day, sex, and survey hospital; and (2) age, sex, and survey hospital. Conditional logistic regression analysis was performed to obtain odds ratios (ORs) for long survival.

RESULTS:

Patients with a long duration of T2DM had a mean (± SD) age of 75 ± 10 years. Their T2DM had been diagnosed at a mean age of 32 years and the median duration of diabetes was 41 years. In both case-control studies, long-duration T2DM was associated with an increased risk of hyperglycemia (OR 6.31; 95% confidence interval [CI] 1.89-21.09) and coronary heart disease (CHD; OR 2.18 95% CI 1.01-4.70). However, long-duration T2DM was not associated with a higher likelihood of abnormal lipids, diabetic nephropathy (DN), or stroke compared with patients with a shorter duration of T2DM.

CONCLUSIONS:

The present study suggests that Chinese patients with long-term T2DM also had increased risks of hyperglycemia and non-fatal CHD. Further studies are needed to investigate whether survival of these patients was associated with non-increased risk of DN.

KEYWORDS:

; Chinese; diabetic nephropathy; long-term diabetes; long-term survivors; type 2 diabetes mellitus

PMID:
26754351
DOI:
10.1111/1753-0407.12375
[Indexed for MEDLINE]

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