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Trends Endocrinol Metab. 2016 Feb;27(2):105-117. doi: 10.1016/j.tem.2015.12.001. Epub 2016 Jan 2.

Mitochondrial Dynamics and Metabolic Regulation.

Author information

1
Institute for Genetics, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
2
Institute for Genetics, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany; Max-Planck-Institute for Biology of Aging, Cologne, Germany. Electronic address: thomas.langer@uni-koeln.de.

Abstract

Mitochondrial morphology varies tremendously across cell types and tissues, changing rapidly in response to external insults and metabolic cues, such as nutrient status. The many functions of mitochondria have been intimately linked to their morphology, which is shaped by ongoing events of fusion and fission of outer and inner membranes (OM and IM). Unopposed fission causes mitochondrial fragmentation, which is generally associated with metabolic dysfunction and disease. Unopposed fusion results in a hyperfused network and serves to counteract metabolic insults, preserve cellular integrity, and protect against autophagy. Here, we review the ways in which metabolic alterations convey changes in mitochondrial morphology and how disruption of mitochondrial morphology impacts cellular and organismal metabolism.

KEYWORDS:

fission; fusion; metabolism; mitochondria; mitochondrial dynamics

PMID:
26754340
DOI:
10.1016/j.tem.2015.12.001
[Indexed for MEDLINE]

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