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J Thorac Oncol. 2016 May;11(5):e55-e58. doi: 10.1016/j.jtho.2015.12.097. Epub 2015 Dec 29.

A Case of ALK-Rearranged Adenocarcinoma with Small Cell Carcinoma-Like Transformation and Resistance to Crizotinib.

Author information

1
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
2
Department of Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
3
Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
4
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: shimhs@yuhs.ac.

Abstract

Histologic changes can be involved in resistance to anticancer drugs. Transformation to small cell lung carcinoma (SCLC) following treatment with EGFR tyrosine kinase inhibitors has been reported in patients with EGFR-mutant lung adenocarcinoma. Herein, we report a case of ALK-rearranged lung adenocarcinoma with SCLC-like histology in a metastatic abdominal nodule that was resistant to crizotinib therapy.

KEYWORDS:

Anaplastic lymphoma kinase; Crizotinib; Lung adenocarcinoma; Resistance; Small cell lung carcinoma

PMID:
26752677
DOI:
10.1016/j.jtho.2015.12.097
[Indexed for MEDLINE]
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