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Int J Pharm. 2016 Feb 29;499(1-2):263-270. doi: 10.1016/j.ijpharm.2015.12.067. Epub 2016 Jan 2.

Multimodal approach to characterization of hydrophilic matrices manufactured by wet and dry granulation or direct compression methods.

Author information

1
Institute of Technology, The Pedagogical University of Cracow, ul. Podchorążych 2, 30-084 Kraków, Poland.
2
Department of Pharmaceutical Technology and Biopharmaceutics, Pharmaceutical Faculty, Jagiellonian University, ul. Medyczna 9, 30-688 Kraków, Poland.
3
Physiolution GmbH, Walther-Rathenau-Strasse 49a, 17489 Greifswald, Germany.
4
Department of Pharmaceutical Technology, Pharmaceutical Faculty, Wrocław Medical University, ul. Borowska 211A, 50-556 Wrocław, Poland.
5
Department of Magnetic Resonance Imaging, Institute of Nuclear Physics PAN, ul. Radzikowskiego 152, 31-342 Kraków, Poland.
6
Department of Well Logging, Oil and Gas Institute-National Research Institute, ul. Bagrowa 1, 30-733, Kraków, Poland.
7
Department of Pharmaceutical Technology and Biopharmaceutics, Pharmaceutical Faculty, Jagiellonian University, ul. Medyczna 9, 30-688 Kraków, Poland. Electronic address: mfdorozy@cyf-kr.edu.pl.

Abstract

PURPOSE OF THE RESEARCH:

The purpose of the research was to investigate the effect of the manufacturing process of the controlled release hydrophilic matrix tablets on their hydration behavior, internal structure and drug release. Direct compression (DC) quetiapine hemifumarate matrices and matrices made of powders obtained by dry granulation (DG) and high shear wet granulation (HS) were prepared. They had the same quantitative composition and they were evaluated using X-ray microtomography, magnetic resonance imaging and biorelevant stress test dissolution.

PRINCIPAL RESULTS:

Principal results concerned matrices after 2 h of hydration: (i) layered structure of the DC and DG hydrated tablets with magnetic resonance image intensity decreasing towards the center of the matrix was observed, while in HS matrices layer of lower intensity appeared in the middle of hydrated part; (ii) the DC and DG tablets retained their core and consequently exhibited higher resistance to the physiological stresses during simulation of small intestinal passage than HS formulation.

MAJOR CONCLUSIONS:

Comparing to DC, HS granulation changed properties of the matrix in terms of hydration pattern and resistance to stress in biorelevant dissolution apparatus. Dry granulation did not change these properties-similar hydration pattern and dissolution in biorelevant conditions were observed for DC and DG matrices.

KEYWORDS:

Biorelevant stress test dissolution; Direct compression; Dry granulation; High shear granulation; Magnetic Resonance Imaging (MRI); Quetiapine controlled release tablets; X-ray microtomography (μCT, Micro-CT)

PMID:
26752087
DOI:
10.1016/j.ijpharm.2015.12.067
[Indexed for MEDLINE]

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