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J Clin Endocrinol Metab. 2016 Mar;101(3):923-7. doi: 10.1210/jc.2015-3767. Epub 2016 Jan 11.

Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women.

Author information

1
Departments of Nutrition Science (B.R.M., L.M., C.M.W.), Statistics (G.P.M.), and Physics (G.S.J.), Purdue University, West Lafayette, Indiana 47907-2059; Nestle Research Center (M.N.H., E.O.-C.), 1000 Lausanne, Switzerland; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46202.

Abstract

CONTEXT:

Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats.

OBJECTIVE:

The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women.

DESIGN:

The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healthy postmenopausal women. Bone calcium retention was determined from urinary excretion of the rare isotope, (41)Ca, from bone.

RESULTS:

Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5% (P < .04).

CONCLUSION:

Calcium supplementation (Calcilock), in combination with hesperidin, is effective at preserving bone in postmenopausal women.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01881204.

PMID:
26751193
DOI:
10.1210/jc.2015-3767
[Indexed for MEDLINE]
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