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PLoS One. 2016 Jan 11;11(1):e0146397. doi: 10.1371/journal.pone.0146397. eCollection 2016.

Decreased Interleukin-10 Responses in Children with Severe Mycoplasma pneumoniae Pneumonia.

Author information

1
Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
2
Department of Microbiology, Anhui Medical University, Hefei, Anhui, China.
3
Department of Clinical Laboratory, Fuyang Second People's Hospital, Fuyang, Anhui, China.
4
Department of Respiratory Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Abstract

Several cytokines may play roles in the immunological pathogenesis of mycoplasmal pneumonia caused by Mycoplasma pneumoniae. In this study, we investigated serum cytokine profiles in children with mycoplasmal pneumonia. The serum levels of interleukin (IL)-8, IL-10, and IL-18 were examined using ELISA kits in 34 patients with M. pneumoniae infection (Group 1, 11 with severe mycoplasmal pneumonia; Group 2, 13 with mild mycoplasmal pneumonia; Group 3, 10 with asthma) and 32 age-matched, non-infected controls. The serum levels of IL-8, IL-10, and IL-18 increased significantly in patients with mycoplasmal pneumonia compared with those in controls (P<0.01). The serum levels of IL-10 decreased significantly in Group 1 compared with those in Group 2 (P<0.01). The serum levels of IL-18 increased significantly in Group 1 compared with those in Group 2 (P<0.01). The serum levels of IL-10 and IL-18 decreased significantly in 10 M. pneumoniae-infected patients with asthma compared with those in 24 M. pneumoniae-infected patients without asthma (P<0.01). We examined the level of interleukins (IL-8, IL-10 and IL-18) after the patients started therapy. The data showed that IL-18 were lower after therapy (P<0.01). Collectively, our data suggested that these cytokines may be involved in the pathogenesis of mycoplasmal pneumonia.

PMID:
26751073
PMCID:
PMC4708986
DOI:
10.1371/journal.pone.0146397
[Indexed for MEDLINE]
Free PMC Article

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