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Proteomics. 2016 Apr;16(8):1238-50. doi: 10.1002/pmic.201500374. Epub 2016 Mar 31.

Advancing translational research with next-generation protein microarrays.

Author information

1
State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (The PHOENIX Center, Beijing), Beijing, P. R. China.
2
The Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.

Abstract

Protein microarrays are a high-throughput technology used increasingly in translational research, seeking to apply basic science findings to enhance human health. In addition to assessing protein levels, posttranslational modifications, and signaling pathways in patient samples, protein microarrays have aided in the identification of potential protein biomarkers of disease and infection. In this perspective, the different types of full-length protein microarrays that are used in translational research are reviewed. Specific studies employing these microarrays are presented to highlight their potential in finding solutions to real clinical problems. Finally, the criteria that should be considered when developing next-generation protein microarrays are provided.

KEYWORDS:

Biomarker; In vitro diagnostics; Protein microarray; Translational research

PMID:
26749402
DOI:
10.1002/pmic.201500374
[Indexed for MEDLINE]

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