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Anaesthesia. 2016 Apr;71(4):405-10. doi: 10.1111/anae.13368. Epub 2016 Jan 8.

A randomised controlled trial of peri-operative lidocaine infusions for open radical prostatectomy.

Author information

1
Anaesthesia, Peri-operative and Pain Medicine, University of Melbourne, Melbourne, Victoria, Australia.
2
Department of Anaesthesia, Eastern Health, Box Hill, Victoria, Australia.
3
Department of Anaesthesia, Monash Health, Clayton, Victoria, Australia.
4
Acute Pain Service, Austin Hospital, Heidelberg, Victoria, Australia.
5
Department of Anaesthesia, Austin Hospital, Heidelberg, Victoria, Australia.
6
School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia.
7
Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.

Erratum in

Abstract

We allocated 76 men scheduled for radical retropubic prostatectomy to peri-operative lidocaine 2% or saline 0.9%: a pre-operative 0.075 ml.kg(-1) intravenous bolus; an intra-operative intravenous infusion at 0.075 ml.kg(-1) .h(-1) ; and 24 hours' postoperative subcutaneous infusion at 0.075 ml.kg(-1) .h(-1) . Lidocaine reduced the postoperative hospital stay by a mean (95% CI) of 1.3 (0.3-2.4) days, p = 0.017, from a mean (SD) of 4.6 (3.2) days with saline. There were no significant differences in pain at rest or on coughing at 24 h. [corrected]. Lidocaine reduced 24-h morphine consumption by a mean (95% CI) of 13.9 (2.2-25.7) mg, p = 0.021, from a mean (SD) of 52.3 (26.9) mg with saline. There were no differences in other outcomes.

PMID:
26749026
PMCID:
PMC4849200
DOI:
10.1111/anae.13368
[Indexed for MEDLINE]
Free PMC Article

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