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Cell Stem Cell. 2016 Jan 7;18(1):7-9. doi: 10.1016/j.stem.2015.12.008.

Lifting the Mist on Gastric Stem Cells.

Author information

1
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany.
2
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany. Electronic address: greten@gsh.uni-frankfurt.de.

Abstract

In a recent issue of Cancer Cell, Hayakawa et al. (2015) demonstrate that Mist1(+) gastric stem cells are supported by a specialized niche composed of Cxcl12(+) endothelium and Wnt5a-producing Cxcr4(+) innate lymphoid cells. In diffuse-type gastric cancer this perivascular stem cell niche is expanded and can be exploited for cancer therapy.

PMID:
26748749
DOI:
10.1016/j.stem.2015.12.008
[Indexed for MEDLINE]
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