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Cell Rep. 2016 Jan 12;14(2):208-15. doi: 10.1016/j.celrep.2015.12.026. Epub 2015 Dec 31.

Cortical Sensory Responses Are Enhanced by the Higher-Order Thalamus.

Author information

1
Institute for Neuroscience, Technische Universität München, Biedersteiner Straβe 29, 80802 Munich, Germany.
2
Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straβe 22, 81675 Munich, Germany. Electronic address: alexander.groh@gmail.com.

Abstract

In the mammalian brain, thalamic signals reach the cortex via two major routes: primary and higher-order thalamocortical pathways. While primary thalamocortical nuclei transmit sensory signals from the periphery, the function of higher-order thalamocortical projections remains enigmatic, in particular their role in sensory processing in the cortex. Here, by optogenetically controlling the thalamocortical pathway from the higher-order posteromedial thalamic nucleus (POm) during whisker stimulation, we demonstrate the integration of the two thalamocortical streams by single pyramidal neurons in layer 5 (L5) of the mouse barrel cortex under anesthesia. We report that POm input mainly enhances sub- and suprathreshold activity via net depolarization. Sensory enhancement is accompanied by prolongation of cortical responses over long (800-ms) periods after whisker stimulation. Thus, POm amplifies and temporally sustains cortical sensory signals, possibly serving to accentuate highly relevant sensory information.

PMID:
26748702
DOI:
10.1016/j.celrep.2015.12.026
[Indexed for MEDLINE]
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