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Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Mar;121(3):301-6. doi: 10.1016/j.oooo.2015.10.024. Epub 2015 Nov 4.

Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma.

Author information

1
Department of Oral and Maxillofacial Surgery, University Hospital Tuebingen, 72076 Tuebingen, Germany. Electronic address: dr.dr.martingrimm@googlemail.com.
2
Zyagnum AG, 64319 Pfungstadt, Germany.
3
Biovis' Diagnostik MVZ, 65555 Limburg an der Lahn, Germany.
4
Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.
5
Department of Oral and Maxillofacial Surgery, University Hospital Tuebingen, 72076 Tuebingen, Germany.

Abstract

OBJECTIVES:

Monocytes/macrophages are regarded as the first line of defense in tumors. Therefore, analyzing monocyte subtypes in oral squamous cell carcinoma (OSCC) may be of value in disease monitoring and to explore immunotherapeutic strategies for cancer patients.

STUDY DESIGN:

Circulating peripheral blood CD14+/CD16+ monocyte-derived macrophages (MDMs) were evaluated in OSCC patients with oral squamous cell carcinoma (n = 44) compared with controls (n = 85). Moreover, epitope detection in monocytes (EDIM) technology was used to detect biomarkers Apo10 and transketolase-like-1 in CD14+/CD16+ MDMs.

RESULTS:

Compared with controls, no significant (P = .3646) difference (control group 9.8%, OSCC group 8.8%) in CD14+/CD16+ MDM were noted in OSCC. However, EDIM-Apo10 and EDIM-TKTL1 scores detected in the CD14+/CD16+ MDMs were increased in OSCC compared with controls (P < .0001).

CONCLUSIONS:

Analyzing CD14+/CD16+ MDMs represents a stable cell population for detecting biomarkers in cancer disease monitoring.

PMID:
26747736
DOI:
10.1016/j.oooo.2015.10.024
[Indexed for MEDLINE]

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