Format

Send to

Choose Destination
See comment in PubMed Commons below
J Stem Cell Transplant Biol. 2015;1(1). pii: 104. Epub 2015 Apr 20.

Heart Regeneration with Embryonic Cardiac Progenitor Cells and Cardiac Tissue Engineering.

Author information

  • 1Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI 48109, USA.
  • 2Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109, USA.
  • 3Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109, USA; Macromolecular Science and Engineering Center, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Materials Science and Engineering, The University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Myocardial infarction (MI) is the leading cause of death worldwide. Recent advances in stem cell research hold great potential for heart tissue regeneration through stem cell-based therapy. While multiple cell types have been transplanted into MI heart in preclinical studies or clinical trials, reduction of scar tissue and restoration of cardiac function have been modest. Several challenges hamper the development and application of stem cell-based therapy for heart regeneration. Application of cardiac progenitor cells (CPCs) and cardiac tissue engineering for cell therapy has shown great promise to repair damaged heart tissue. This review presents an overview of the current applications of embryonic CPCs and the development of cardiac tissue engineering in regeneration of functional cardiac tissue and reduction of side effects for heart regeneration. We aim to highlight the benefits of the cell therapy by application of CPCs and cardiac tissue engineering during heart regeneration.

KEYWORDS:

Biomaterials; Cardiac progenitor cells; Cardiac tissue engineering; Cell therapy; Heart regeneration; Myocardial infarction

PMID:
26744736
PMCID:
PMC4701050
DOI:
10.19104/jstb.2015.104
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center