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Eur J Med Res. 2016 Jan 8;21:1. doi: 10.1186/s40001-015-0194-5.

Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study.

Author information

1
Subdivision MOVEFIT-Sports Medicine, Department of Rehabilitation Medicine, Erasmus University Medical Center, Wytemaweg 80, 3000 CA, Rotterdam, The Netherlands. r.rozenberg@erasmusmc.nl.
2
Subdivision MOVEFIT-Sports Medicine, Department of Rehabilitation Medicine, Erasmus University Medical Center, Wytemaweg 80, 3000 CA, Rotterdam, The Netherlands. r.mankowski@ufl.edu.
3
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands. l.vanloon@maastrichtuniversity.nl.
4
Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. j.langendonk@erasmusmc.nl.
5
Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. e.sijbrands@erasmusmc.nl.
6
Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. a.vandenmeiracker@erasmusmc.nl.
7
Subdivision MOVEFIT-Sports Medicine, Department of Rehabilitation Medicine, Erasmus University Medical Center, Wytemaweg 80, 3000 CA, Rotterdam, The Netherlands. h.j.stam@erasmusmc.nl.
8
Subdivision MOVEFIT-Sports Medicine, Department of Rehabilitation Medicine, Erasmus University Medical Center, Wytemaweg 80, 3000 CA, Rotterdam, The Netherlands. s.praet@erasmusmc.nl.

Abstract

OBJECTIVE:

The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2).

METHODS:

Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20% Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained.

RESULTS:

Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min(-1)); 18.5 ± 1.5 (5 L min(-1)); 21.7 ± 1.7 (10 L min(-1)); 24.0 ± 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air.

CONCLUSIONS:

An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

PMID:
26744210
PMCID:
PMC4705628
DOI:
10.1186/s40001-015-0194-5
[Indexed for MEDLINE]
Free PMC Article

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