Format

Send to

Choose Destination
Bioinformatics. 2016 May 1;32(9):1414-6. doi: 10.1093/bioinformatics/btv769. Epub 2016 Jan 6.

MAESTROweb: a web server for structure-based protein stability prediction.

Author information

1
Department of Molecular Biology, University of Salzburg, Salzburg 5020 School of Informatics, Communications and Media, University of Applied Sciences Upper Austria, Hagenberg 4232, Austria.
2
School of Informatics, Communications and Media, University of Applied Sciences Upper Austria, Hagenberg 4232, Austria.
3
Department of Molecular Biology, University of Salzburg, Salzburg 5020.

Abstract

The prediction of change in stability upon point mutations in proteins has many applications in protein analysis and engineering. We recently adjoined a new structure-based method called MAESTRO, which is distributed as command line program. We now provide access to the most important features of MAESTRO by an easy to use web service. MAESTROweb allows the prediction of change in stability for user-defined mutations, provides a scan functionality for the most (de)stabilizing n-point mutations for a maximum of n = 5, creates mutation sensitivity profiles and evaluates potential disulfide bonds. MAESTROweb operates on monomers, multimers and biological assemblies as defined by PDB.

AVAILABILITY AND IMPLEMENTATION:

MAESTROweb is freely available for non-commercial use at https://biwww.che.sbg.ac.at/maestro/web

CONTACT:

peter.lackner@sbg.ac.at.

PMID:
26743508
DOI:
10.1093/bioinformatics/btv769
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center