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Am J Med. 2016 Apr;129(4):354-65. doi: 10.1016/j.amjmed.2015.12.005. Epub 2015 Dec 29.

Present and Future of Cardiac Troponin in Clinical Practice: A Paradigm Shift to High-Sensitivity Assays.

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Division of Cardiology, Department of Medicine, Hennepin County Medical Center, Minneapolis, Minn; Minneapolis Heart Institute, Abbott-Northwestern Hospital, Minn. Electronic address:
Department of Emergency Medicine, Hennepin County Medical Center and University of Minnesota, Minneapolis.
Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota, Minneapolis.


Despite its wide utilization and central role in the evaluation of patients with potential ischemic symptoms, misconceptions and confusion about cardiac troponin (cTn) prevail. The implementation of high-sensitivity (hs) cTn assays in clinical practice has multiple potential advantages provided there is an education process tied to the introduction of these assays that emphasizes the appropriate utilization of the test. Several diagnostic strategies have been explored with hs-cTn assays, including the use of undetectable values, accelerated serial hs-cTn sampling, hs-cTn measurements in combination with a clinical-risk score, and the use of a single hs-cTn measurement with a concentration threshold tailored to meet a clinical need. In this document we discuss basic concepts that should facilitate the integration of hs-cTn assays into clinical care in years to come.


Acute myocardial infarction; High-sensitivity cardiac troponin; Troponin

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