Ultrahigh (19)F Loaded Cu1.75S Nanoprobes for Simultaneous (19)F Magnetic Resonance Imaging and Photothermal Therapy

ACS Nano. 2016 Jan 26;10(1):1355-62. doi: 10.1021/acsnano.5b06759. Epub 2016 Jan 12.

Abstract

(19)F magnetic resonance imaging (MRI) is a powerful noninvasive, sensitive, and accurate molecular imaging technique for early diagnosis of diseases. The major challenge of (19)F MRI is signal attenuation caused by the reduced solubility of probes with increased number of fluorine atoms and the restriction of molecular mobility. Herein, we present a versatile one-pot strategy for the fabrication of a multifunctional nanoprobe with high (19)F loading (∼2.0 × 10(8 19)F atoms per Cu1.75S nanoparticle). Due to the high (19)F loading and good molecular mobility that results from the small particle size (20.8 ± 2.0 nm) and ultrathin polymer coating, this nanoprobe demonstrates ultrahigh (19)F MRI signal. In vivo tests show that this multifunctional nanoprobe is suitable for (19)F MRI and photothermal therapy. This versatile fabrication strategy has also been readily extended to other single-particle nanoprobes for ablation and sensitive multimodal imaging.

Keywords: 19F MRI; copper sulfide nanoparticle; multifunctional nanoprobes; photothermal imaging and therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Contrast Media / administration & dosage
  • Copper / chemistry*
  • Female
  • Fluorine Radioisotopes / administration & dosage
  • Fluorine-19 Magnetic Resonance Imaging / methods*
  • HeLa Cells
  • Humans
  • Injections, Subcutaneous
  • Mammary Glands, Animal
  • Mammary Neoplasms, Experimental / pathology
  • Mammary Neoplasms, Experimental / therapy*
  • Mice
  • Mice, Inbred BALB C
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Particle Size
  • Phototherapy / methods*

Substances

  • Contrast Media
  • Fluorine Radioisotopes
  • Copper
  • cupric sulfide