Format

Send to

Choose Destination
Neurobiol Learn Mem. 2016 Feb;128:40-5. doi: 10.1016/j.nlm.2015.12.005. Epub 2015 Dec 29.

Acquisition of specific response-outcome associations requires NMDA receptor activation in the basolateral amygdala but not in the insular cortex.

Author information

1
INRA, Nutrition and Integrative Neurobiology, UMR 1286, 33076 Bordeaux, France; CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, 33076 Bordeaux, France; Université de Bordeaux, 33076 Bordeaux, France. Electronic address: shauna.parkes@u-bordeaux.fr.
2
INRA, Nutrition and Integrative Neurobiology, UMR 1286, 33076 Bordeaux, France; Université de Bordeaux, 33076 Bordeaux, France.
3
CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, 33076 Bordeaux, France; Université de Bordeaux, 33076 Bordeaux, France.

Abstract

The basolateral amygdala (BLA) and the gustatory region of the insular cortex (IC) are required for the encoding and retrieval of outcome value. Here, we examined if these regions are also necessary to learn associations between actions and their outcomes. Hungry rats were first trained to press two levers for a common outcome. Next, specific response-outcome (R-O) associations were introduced such that each response now earned a distinct food outcome. Prior to each specific R-O training session, rats received a bilateral infusion of the N-methyl-D-aspartate (NMDA) receptor antagonist, DL-APV, into either the BLA or the IC. One of the two outcomes was then devalued immediately prior to a choice test. Inhibition of NMDA receptor activity in the BLA, but not the IC, during the acquisition of specific R-O associations abolished selective devaluation. These results indicate that the BLA is critical for learning the association between actions and their specific consequences.

KEYWORDS:

Acquisition; Amygdala; Conditioning; Goal-directed behavior; Instrumental; Insular cortex

PMID:
26740161
DOI:
10.1016/j.nlm.2015.12.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center