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Org Biomol Chem. 2016 Feb 7;14(5):1559-63. doi: 10.1039/c5ob02482j.

Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay.

Author information

1
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.
2
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk.
3
Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.

Abstract

During efforts to prepare the known compound , a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.

PMID:
26740124
PMCID:
PMC4730866
DOI:
10.1039/c5ob02482j
[Indexed for MEDLINE]
Free PMC Article

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