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Trends Cell Biol. 2016 Feb;26(2):77-79. doi: 10.1016/j.tcb.2015.11.005. Epub 2015 Dec 28.

Reverse Genetics in Zebrafish: Mutants, Morphants, and Moving Forward.

Author information

1
Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: nathan.lawson@umassmed.edu.

Abstract

Gene editing in zebrafish has begun to reveal discordance between mutant phenotypes and those associated with knockdown via morpholino oligonucleotides (MOs). These studies suggest that MOs should not be used as a standalone tool and underscore the need for guidelines that require defined mutants to assess gene function in zebrafish.

PMID:
26739910
DOI:
10.1016/j.tcb.2015.11.005
[Indexed for MEDLINE]

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