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Free Radic Biol Med. 1989;7(3):333-49.

Biological interactions of alpha,beta-unsaturated aldehydes.

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UMDNJ--Robert Wood Johnson Medical School, Department of Environmental and Community Medicine, Piscataway 08854.


This article describes the chemical nature of alpha,beta-unsaturated aldehydes and some of their toxicological effects based on their ability to function as direct-acting alkylating agents. Selected compounds discussed include alpha,beta-unsaturated aldehydic environmental pollutants, metabolites of xenobiotics and natural products, and lipid peroxidation--and DNA oxidation products derived from cellular constituents. Briefly reviewed are sources and mechanisms of formation of the aldehydes, their reactivity with respect to glutathione and amino-groups, their toxicity based on interaction with sulfhydryl and amino targets in cells, and modulation of their toxicity by metabolism.

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