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Fitoterapia. 2016 Mar;109:266-73. doi: 10.1016/j.fitote.2015.12.018. Epub 2015 Dec 29.

Hepatoprotective triterpenes from the gum resin of Boswellia carterii.

Author information

1
Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, People's Republic of China. Electronic address: wangyg84@126.com.
2
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyan 473061, People's Republic of China. Electronic address: maqinge2006@163.com.
3
College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, People's Republic of China. Electronic address: pstianjin@126.com.
4
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: renjin5@163.com.
5
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: wangaiguo@imm.ac.cn.
6
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: jitf@imm.ac.cn.
7
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: yjb@imm.ac.cn.
8
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: suyalun@imm.ac.cn.

Abstract

Ten tirucallane-type triterpenes named boscartene A-J and a nor-tetracyclic triterpene boscartene K, together with ten known compounds were isolated from the gum resin of Boswellia carterii Birdw. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis. In vitro assay, some of these compounds (10 μM) showed moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage.

KEYWORDS:

Boscartene A–K; Boswellia carterii; Hepatoprotective activities; Tirucallane-type triterpenes

PMID:
26739386
DOI:
10.1016/j.fitote.2015.12.018
[Indexed for MEDLINE]

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